AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Chrome trace adkins4/28/2023 ![]() The chorus emphasizes her attraction to chrome while dismissing other colors like pink and purple paisleys or mellow yellow daisies. She prefers to ride in a big black Mack truck with a smokestack pointed towards the sky and mud flaps, and even expresses a desire to drive it herself. She is drawn to the power and style of a red Chevelle with white wheels or an Electra Glide motorcycle with dual tailpipes. The lyrics describe a girl who is enamored by the shine and beauty of chrome, and who finds it more appealing than any other color. The song "Chrome" by Trace Adkins is a tribute to the love for cars and motorcycles, with an emphasis on the beauty of chrome. She climbed inside and said, "hell no, I wanna drive" This article is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License, which means that you can copy and modify it as long as the entire work (including additions) remains under this license.With a smoke stack pointed towards the skyĬhrome, I said, "hey little girl, you sure look nice This page contains text from Wikipedia, the Free Encyclopedia. ![]() If an internal link led you here, you may wish to change the link to point directly to the intended article. This disambiguation page lists articles associated with the same title.
0 Comments
Read More
Back to Blog
3s0 red pill4/28/2023 The forum specifically advocates for the so-called “men’s rights” movement, which often bills itself as being about restoring men’s self-esteem after it’s been damaged by the effects of feminism, protecting fathers’ agency in custody battles, and generally restoring their traditional roles as head of the family. Writing under a number of aliases, Fisher made several dismissive statements about sexual consent and the inferiority of womenįisher has espoused typical alt-right ideological views online, even though he only served as moderator of TheRedPill for around two months between late 2012 and early 2013. Instead, he seems to be embracing his role as a de facto leader of the alt-right enclave, and says he will “stand strong for men's rights” in the New Hampshire legislature. Now greeting the accusations - which include a litany of misogynistic comments posted to the forum over the years - with a mix of denial and admission, Fisher is ignoring calls from his fellow state legislators to resign. In 2014, he campaigned as a Republican, won, and maintained his seat in 2016 with a total of 5,700 votes. Fisher created r/TheRedPill near the end of his initial campaign for the New Hampshire state House of Representatives, in which he ran as a Democrat. The Daily Beast has uncovered significant evidence that TheRedPill’s founder, a redditor named pk_atheist, is actually a state Republican lawmaker.Īccording to the Daily Beast’s findings, pk_atheist is one of many internet handles belonging to a 31-year-old Republican lawmaker named Robert Fisher. ![]() Now it appears the foundational beliefs of TheRedPill could be directly impacting politics in at least one state. An appropriation of The Matrix’s concept of “taking the red pill,” members of the forum argue that men need to “wake up” to a reality in which feminism has ruined their lives. It might’ve been made differently from your old brand, and if so, there’s a chance it might not be safe to split.Since its founding in 2012, the “men’s rights” subreddit r/TheRedPill has become one of the most notorious forums in Reddit’s history, widely known as a misogynistic cesspool in which men deride feminist ideologies and mock rape victims. If you start taking a different brand of the same medication, ask your doctor or pharmacist if it’s safe to split the new tablet. Don’t cut them all at once because things like heat, humidity, and moisture can affect split tablets that you keep stored. Only split the tablet that you’re about to take. Check with your doctor or pharmacist first. Still, a tablet splitter isn’t guaranteed to be the right tool for the job, because some pills have a unique size or shape. If your doctor or pharmacist tells you to split your tablets, ask them if you should use a device called a “tablet splitter” or a “pill cutter.” It can help you make sure you get the correct dose. Or they might recommend it to help you save money, since certain double-strength tablets cost about as much as lower-dose versions. They might have you split your pills to change the dose of your medication. Only split a tablet if your pharmacist or doctor tells you to do it and explains how. Some tablets don’t have any score marks, which means it may be unsafe to cut them. The notch is called a “score.” It shows you where you can split or cut a tablet. Some pills have a shallow notch cut into the surface of the tablet.
Back to Blog
2015 honda odyssey4/28/2023 A 2.2-liter, four-cylinder engine with 140 horsepower and a 4-speed transmission were features of the first Odyssey. The original Honda Odyssey could comfortably accommodate six or seven passengers. Instead, they swung outward on hinges like standard vehicle doors. The Odyssey’s rear doors did not slide outward like most other minivans on the market at the time. The Odyssey was constructed by Honda using the Accord platform and many of the same parts. Honda released their first minivan, the Odyssey in 1995. Honda Odyssey Generations First Generation (1995 – 1998) We will further look at the best and worst year for the Honda Odyssey. Particularly the 2017 model, with simple routine maintenance, might last up to 300,000 miles. This alone compromises the argument that Honda is among the most long lasting car brands, with bulletproof reliability. Some of them were unable to be driven for more than 100,000 miles. However, since 2016, both the minivan series itself and its reputation for reliability have seen a rebound.įor a very long time, transmission problems severely constrained how long these cars could be driven. The Odysseys of the following generations, the second and third, did not meet that criterion. These minivans from the first generation were among the most dependable models ever made. The entire series is generally quite reliable. Without further ado, let’s examine Odyssey’s past to learn what years of Honda Odyssey to avoid and everything else you should know before purchasing one used. Honda vehicles are known for being very affordable and having a lengthy lifespan. Buying A Honda OdysseyĪccording to Edmunds, the price of the 2022 Odyssey ranges from $32,290 to $48,020, depending on the trim level and accessories. You can choose from five available trim levels and it continues to be the best minivan, according to many critics. Present-day models have a 3.5-liter V6 engine with 280 horsepower, eight seats, and a large amount of cargo space. This is a similar system to those minivans with stow and go seats. For instance, the Odyssey features second-row seats that are detachable for more cargo space. Buyers frequently compare the Odyssey with other Honda models, including the Pilot.īut usually, it is clear that the Odyssey offers much greater convenience and practicality. ![]() It has a sizable cargo area that can accommodate several bulky, items. The Honda Odyssey has roomy seating for up to eight people. The present model offers a variety of convenience features to maximize the comfort of the passengers and the enjoyment of driving, unlike the previous model with hinged doors and limited horsepower. The Honda Odyssey has seen five generations of enhancements and changes. It is currently in its fifth iteration, which debuted in 2018. ![]() The Honda Odyssey is a minivan marketed by Honda since 1994. ![]() Use this guide to determine the Honda Odyssey model years and the years to stay away from. So when making your next buy, you can think about a used model. ![]() The cost of a new Honda Odyssey is still high. In a steadily fading niche, this popular minivan keeps wowing the crowd. The Honda Odyssey is one of the most esteemed and well-liked family haulers. Here we’ll look at what years of Honda Odyssey to avoid along with the most common problems across the years. However, it has nonetheless attracted a lot of attention throughout the years because it is made by Honda. This minivan isn’t the most fashionable vehicle and only appeals to specific buyers. The Honda Odyssey is not the most popular model of the automaker.
Back to Blog
Hot pocket flavors4/28/2023 For product news and information, visit or /NestleUSA.Go big or go home with Hot Pockets Big & Bold Chicken Bacon Ranch Blasted Crust Frozen Snacks. in Vevey, Switzerland - the world’s largest food company with a commitment to Nutrition, Health & Wellness - with 2014 sales of $100 billion. Nestlé USA, with 2014 sales of $9.7 billion, is part of Nestlé S.A. From nutritious meals with LEAN CUISINE® to baking traditions with NESTLÉ® TOLL HOUSE®, Nestlé USA makes delicious, convenient, and nutritious food and beverages that make good living possible. Named one of “The World’s Most Admired Food Companies” in Fortune magazine for eighteen consecutive years, Nestlé provides quality brands that bring flavor to life every day. Available in grocers’ freezers, the IRRESISTIBLY HOT ® sandwiches have evolved into an iconic brand that’s become a staple in American pop culture. Made with savory premium meats, buttery seasoned crusts, and real cheese, HOT POCKETS pioneered a new category of frozen sandwiches and snacks, which were acquired by Nestlé in 2002. The suggested retail price is $5.00 for two 9-ounce packs and $5.49 for a 24-ounce pack.įor more about HOT POCKETS, follow us on Facebook ( Twitter ( ) and YouTube ( About HOT POCKETS Brand Sandwichesįor 30 years, HOT POCKETS® and LEAN POCKETS® brand sandwiches have provided hungry consumers a delicious any-time meal or snack, making it the hottest frozen sandwich across America. HOT POCKETS Snack Bites and Breakfast Bites are currently available at all Walmart stores and will be available at all participating retailers nationwide starting June 2015.
Back to Blog
Adobe edge animate cc free4/28/2023 ![]() Support for evolving web standards comes standard. Using Edge Animate, you can create animation and interactivity to produce visuals such as banner ads, slideshows, animations, and other forms of rich media. Adobe Flash Professional is now Animate CC. Doing so is incredibly simple and will only take you a couple of minutes. Adobe Edge Animate CC is a motion graphics creation tool for the web. If you’d like to use this software on a third system, you’ll first have to deactivate it on one of the initial two PCs. Is it possible to install Animate on a different PC/laptop?Īnimate CC along with other Adobe products can be installed on up to 2 devices. Adobe Animate CC (free version) download for PC Windows Photo & Graphics Viewers & Editors Adobe Animate CC Adobe Animate CC Create, customize, preview, and manage 2D animations Download now from developer's website 3.6 on 169 votes 0 /5 stars Developer: Adobe Systems Incorporated License: Shareware 20.Once you buy your subscription, Animate CC will automatically become licensed once you relaunch the software. Yes, during the trial period, you can subscribe either to the All Apps or Single App plan using the official Creative Cloud site. Can I transition from a trial version to a paid membership?. ![]() What formats can Animate CC save files in?Īnimations that you design in this software can be saved in such formats as Flash (SWF), AIR, HTML5 Canvas, and WebGL as well as different video formats and custom extensions like SVG among many others.This software also lets you produce and share your projects via the Creative Cloud library and employ it alongside photo editing software like Photoshop, Illustrator, Muse, and InDesign. What does Animate CC bring to the table?Īnimate CC is deeply integrated with other Adobe products so you can nearly instantly learn how to import, adapt and enhance the various designs that you’ve created in other software. I’m a professional who regularly employs Photoshop, Illustrator, and InDesign.
Back to Blog
Car mechanic simulator 20184/28/2023 ![]() ![]() This download is 100% Free and Hosted on the Fastest Cloud Server.ĭownload How To Download Car Mechanic Simulator 2018 PC Instructions Simulation Video Game, Automotive industry, Racing, Simulation PlayStation 4, Xbox One, Android, Microsoft Windows, Nintendo Switch, iOS Car Mechanic Simulator 2018 PC Game Download Name Optimal rewards after every successful customization encourage the player to play more. While playing this game, it is pretty easy to show your skills as well as your imagination. With cool cars and the zeal to make one with different parts makes it quite excellent. This game is a skillful game that is apt for those who are fanatics for cars. With this game, one can expect to get a natural feel of mechanics. The continuous upgrade in the garage helps the player to get an excellent gaming experience. In this, the player can easily opt for purchasing other parts. The missions are also based upon time constraints that make them quite practical. This game provides unique challenges which are based upon different difficulty levels. The game’s numerous random missions will help you to get engaged in the game fully. It is also equipped with a photo mode through which one can take breathtaking photos. Numerous cars can be purchased from the player’s collection also. With this, the player has got into the shoes of a mechanic and makes themselves work as per their recommendations.Ĭar Mechanic Simulator 2018 features a different approach that includes car auctions which are available for resale. It features more than 40 cars with numerous tools and multiple parts. The detailing of the graphics in this game makes it perfect for those looking for an attractive game. One can get an attractive vehicle by detailing them as per their selection of colors and shades. It also has a Car editor function that helps to make the car as per your choice. The game has numerous classic and unique cars, and the brand new Junkyard Module and Barn Find module. The mechanic works are pretty exciting and also help the players to enjoy. Not only can this help you to create an imaginative design with the true colors of your choice. These are experiences that make any of the games enjoyable. In-Car mechanic 2018, a player gets the authentic feel of painting, tuning, repairing, and driving the cars. The following are some of the features that make it quite enjoyable: When it comes to Car simulator 2018, the features help effectively to understand. The core features of the game define its mettle. The gameplay also engages in examining different components of the vehicles and applying the changes. The player can efficiently perform all the works on cars, such as restoring vintage cars, repairing automobiles, and many more. The gradual increase in the experience points helps to advance the game. The player can access a different set of tools as well as can easily unlock them by completing other jobs. The protagonist can do all the actual work, such as walking freely around the showrooms, barns, and shops. The gameplay of the Car Mechanic Simulator 2018 is quite simplistic. With the release in different genres, it gained massive popularity. It is among the third installment for the Car mechanic simulator franchise. ![]() The simplified mobile version was also released in 2018. For Microsoft Windows, it was released in 2017 and for Nintendo Switch and PlayStation in 2019. It was released for different platforms on subsequent dates. It was developed by Polish studio Red Dot Games, which is based upon the automotive mechanic. Do we need to look for any other specific requirements?Ĭar Mechanic Simulator 2018 is a simulation video game.Can we get our own choice of cars in this game?.Car Mechanic Simulator 2018 – Recommended System Requirement.Car Mechanic Simulator 2018 – Minimum System Requirement.How To Download Car Mechanic Simulator 2018 PC Instructions.Car Mechanic Simulator 2018 PC Game Download.Features of Car Mechanic Simulator 2018.What is the Car Mechanic Simulator 2018?.
Back to Blog
![]() The lack of any challenge also means everyone will blow through the game’s five levels in about an hour. But I imagine this was primarily aimed at the younger set. ![]() There is a nice little spike towards the end that should have been sprinkled throughout the game. The easy difficulty makes it very accessible but the game could still have used some teeth. The enemies are simply not threatening in the slightest and the bosses have incredibly simple patterns to exploit. I probably died once during the entire game and that was against the final boss. ![]() The one major flaw with the game is that it is too short and easy. The library is filled with the most diversity as its many sub levels use the book theme to send you to different locations such as a land made of cake and even swimming in a tea cup! Mizrabel’s castle is probably the only area you are more than likely to die as it spikes in difficulty. ![]() The Storm serves as a nice middle ground as it is clear things are beginning to ramp up. Here you are accosted by toy soldiers and creepy clowns among some of the best platforming challenges in the game. The Enchanted Forest is the perfect introductory level with its simple mushroom enemies and bats and is followed by Toyland. The many rooms in Mizrabel’s castle whisk you away to a number of exotic locations. The only other items available increase your life bar, points, or grant extra lives. Depending on the level you collect apples/ marbles for ranged attacks but these aren’t in great supply and are weak. The butt bounce also serves as a spring to jump higher when hitting enemies. Mickey is armed with the platforming staple butt bounce as his main form of attack. Although it is short you will enjoy every single moment and for its low price I would still highly recommend it. It also helped that it’s a great game too. Castle of Illusion was one of many second generation titles that really showed off the power of 16-bit technology. Meanwhile the NES was hitting its absolute stride with classic after classic. There were plenty of solid titles in its early years but very few that you would categorize as truly great. It’s a platformer what more do you want?Ĭastle of Illusion’s release was an important milestone for the Genesis. As Mickey you are on a quest so save Minnie from the witch Mizrabel by finding seven magical gems scattered throughout her castle. It could easily be mistaken for a game based on an official Disney movie because of its creative environments. This is a truly great game and was a sign of things to come.Ĭastle of Illusion starring Mickey Mouse was released worldwide in 1990. Their many Disney games were simply phenomenal with Castle of Illusion setting a high bar they would continue to exceed. Sega I feel deserves a lot of the same respect. At a time where LJN and Ocean basically treated any license they bought like garbage Capcom showed that if you treated it with respect those titles could stand shoulder to shoulder with the best on the market. Microsoft recently added Castle of Illusion to its list of backward compatible Xbox 360 titles that play on Xbox One.Capcom usually gets the majority of the praise when the discussing Disney licensed titles. It’s currently being sold for $14.99 on the PlayStation Store, Steam and Xbox Games Store. In the side-scrolling platformer, Mickey Mouse is tasked with rescuing Minnie Mouse from the shape-changing witch Mizrabel and must traverse a fantastical castle to do so.Ĭastle of Illusion was released on PlayStation 3, Windows PC and Xbox 360 in 2013. "For players who own the game, they will be able to re-download it to their respective system at any point in the future - this delisting should not prevent current owners from being able to access the game at a later time."ĭeveloped by Sega Studios Australia, the modern Castle of Illusion served as a re-imagining of the beloved Sega Genesis original released in 1990. "Due to an expiration of business terms, SEGA will no longer be able to sell Castle of Illusion on Xbox Live, PlayStation Network, or Steam, with the current publishing arrangement coming to an end on September 2," the company said in a statement. 2, the publisher confirmed to Polygon today. Sega’s 2013 remake of classic 16-bit platformer Castle of Illusion Starring Mickey Mouse will no longer be available for sale after Sept.
Back to Blog
![]() This doesn't include any other charges associated with the loan, and it doesn't show exactly how expensive a loan actually is. A monthly interest rate is simply how much interest you would be charged in one month. The APY on the account would be: (1 … Small Business Interest Rates: Monthly Interest Rate vs. If interest is compounding daily, that means that there are 365 periods per year and that the periodic interest rate is. The APR - or annual percentage rate - is a .The interest rate is the cost of borrowing the principal loan amount.The interest rate does not include fees charged for the … What's the Difference Between Interest Rate and APR?. An auto loan’s interest rate is the cost you pay each year to borrow money expressed as a percentage. ![]() This doesn’t include any other charges associated with the loan, and it doesn’t show … What is the difference between an interest rate and the Annual. Average annual wages per full-time equivalent dependent employee are obtained by dividing the national-accounts-based total wage bill by the … Small Business Interest Rates: Monthly Interest Rate vs. The OECD (Organization for Economic Co-operation and Development) dataset contains data on average annual wages for full-time and full-year equivalent employees in the total economy. ![]() Weekly … List of countries by average wage - Wikipedia. This is the rate per compounding period, such as per month when your period is year and compounding is 12 times per period. There are many costs associated with taking out a . An annual percentage rate (APR) reflects the mortgage interest rate plus other charges. What is the difference between a mortgage interest rate and. The SOFR Index measures the cumulative impact of compounding the SOFR on a unit of investment over time, with the initial value set to 1.00000000 on April 2, 2018, the first. As an extension of the Secured Overnight Financing Rate (SOFR), the SOFR Averages are compounded averages of the SOFR over rolling 30-, 90-, and 180-calendar day periods. SOFR Averages and Index Data - FEDERAL RESERVE BANK of …. Enter the Annual compound interest rate (AER for savings or APR for a loan) click calculate to show the equivalent monthly compound interest rate and not . If you want to figure out how much interest you'll pay each year, use the annual interest rate and one year as the time. As it helps you identify if it is better to get a lower rate with … Compound Interest vs Simple Interest-What's the Difference?. The difference between interest rates vs annual percentage rates is very important as one can end up paying thousands of dollars more for a mortgage. Compound Interest Rate The compound interest … Interest Rate vs. The formula is as follows: i_monthly = i_annual / 12 where i = interest rate. If it is a simple annual interest rate, divide the rate by 12 to calculate the monthly interest rate. Convert Annual Interest Rates into Monthly. Like an interest rate, the APR is expressed as a percentage. APR is the annual cost of a loan to a borrower - including fees. APR vs Interest Rate - What is the Difference - Bank of America. The effective interest rate describes the full cost of borrowing. 1.Familiarize yourself with the concept of an effective interest rate. By opting for … How to Calculate Effective Interest Rate: Formula & Examples. Annual interest is normally paid at a higher rate because of compounding – instead of paying out monthly the interest can roll up with the sum invested. Fixed rate savings: monthly or annual interest? - Your Money. You'll need to convert from percentage Fill order form Determine mathematic We are online 24/7 Solve mathematic problems Small Business Interest Rates: Monthly Interest Rate vs. To calculate a monthly interest rate, divide the annual rate by 12 to reflect the 12 months in the year. Monthly interest to annual | Math Help. Since both are shown over a single year, they are more accurate than interest rate alone. APYs give you the most accurate idea of an account’s earning potential, while APRs give an idea of what you could owe. Both APY and APR are calculated based on interest rates, but they have additional factors, too. APR vs APY: What's the Difference & Why it Matters | KeyBank - Key.com. The interest rate is the amount of compensation per period for borrowing money and includes the cost of . Borrowers often confuse APR with the interest rate.
Back to Blog
Evo pdf toolkit4/28/2023 ![]() The converter has full support for HTML tags, CSS and JavaScript and for advanced HTML5 features like CSS3, SVG and Web Fonts.It has been designed and tested to work reliably in multithreaded environments and in high traffic websites.The library does not rely on external tools or services and does not require installation or server configuration changes, supporting simple copy deployment.You can find a complete list of all EVO HTML to PDF Converter for. The main features of the HTML to PDF Converter are listed below. NET platform on Windows, the EVO HTML to PDF Converter library is also available on various other platforms in various programming languages like Java, Azure, WinRT and Windows Phone, Mono, Xamarin or. NET combines the powerful printer friendly PDF format with the flexibility of the popular HTML format into a modern tool for creating nicely formatted and easily maintainable PDF reports and documents.īesides. Does not require installation or any third party tools.ĮVO HTML to PDF Converter Library for. The converter has full support for HTML5, CSS3, SVG, Canvas, Web Fonts and JavaScript. NET is a library that can be easily integrated and distributed in your ASP.NET and MVC web sites, desktop applications, Windows services and Azure cloud services to convert web pages, HTML strings and streams to PDF, to images or to SVG and to create nicely formatted and easily maintainable PDF reports and documents. Leave a commentĮVO HTML to PDF Converter for. NET, with full C# source code and detailed description. You can see the live demo for automatically creating table of contents using the HTML to PDF Converter for. BinaryWrite (outPdfBuffer ) // End the HTTP response and stop the current page processing ToString ( ) ) ) // Write the PDF document buffer to HTTP response ![]() ![]() The relevant C# code for automatically creating a table of contents is: protected void convertToPdfButton_Click ( object sender, EventArgs e ) ", outPdfBuffer. You can change the font, color, background using the well known CSS syntax. You can customize the table of contents style for title, for each level of items and for the page numbers. Each item in the table of contents is a link to the corresponding content in the PDF document and when you click on that link the PDF viewer will scroll to that content in PDF document. The automatically generated table of contents is hierarchical, having the items structured on many levels and can contain the page number in PDF for each item. Additionally you can specify the item level in table of contents with ‘ data-toc-level‘ attribute and the bookmark title with ‘ data-toc-title‘ attribute. You can set the attribute ‘ data-toc-item‘ on a HTML element to enable the creation a table of contents entry for that element in PDF. You can also define a table of contents directly in HTML using a set of special attributes. NET can be configured to automatically create a table of contents in PDF document based on H1 to H6 head tags found in HTML document by simply turning on a flag. *Please shift to spanish to purchase a system with spanish components.EVO HTML to PDF Converter for. Only the unallocated memory is reported by Vista.Ĭeleron, Intel, the Intel logo, Intel Atom, Intel Core, Intel Inside, the Intel Inside logo, Intel vPro, Intel Evo, Intel Optane, Intel Xeon Phi, Iris, Itanium, MAX, Pentium, and Xeon are trademarks of Intel Corporation or its subsidiaries. The amount varies depending on the devices that are installed on the computer but is at least 1 MB and can be as such as 1 GB. Windows Vista® automatically allocates a certain amount of memory for system use. Dell Systems with 4GB of memory may show less memory in Microsoft Windows. Due to security reasons for you and Dell, it necessary at delivery to show official ID of the credit card holder used in the purchase. No entitlement for distributors/resellers. Promotions from different sources, such as, printed materials, newspaper, radio, TV or special programs, cannot be combined. Promotions can only be combined according to specific rules on each page. Dell will not be responsible for any additional charge from your credit card. Freights will be included in final price. Pricing, specifications, availability and terms of offers may change without notice.
Back to Blog
Marta animal gallego4/27/2023 ![]() ![]() Several recent studies have provided strong evidence confirming the hypothesis that exposure to infections can be a driver of clonal evolution of preleukemic cells toward overt leukemia ( 5–11). This clinically silent preleukemic condition is estimated to be present in more than 5% of the healthy childhood population and does not evolve to disease in the vast majority of cases (4). For many types of childhood B-ALL, there exists a latent preleukemic phase in which the initiating somatic or germline genetic event is present, but leukemia does not develop. ![]() These findings provide the first in vivo evidence for a potential strategy to prevent B-ALL development.ī-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer and greatest cause of cancer-related death in children ( 1–3). Ruxolitinib treatment preferentially targeted Pax5 +/− versus wild-type B-cell progenitors and exerted unique effects on the Pax5 +/− B-cell progenitor transcriptional program. Here we show in Pax5 +/− mice that transient, early-life administration of clinically relevant doses of ruxolitinib, a JAK1/2 inhibitor, significantly mitigates the risk of B-ALL following exposure to infection 1 of 29 animals treated with ruxolitinib developed B-ALL versus 8 of 34 untreated mice. Preclinical studies have shown that this malignant transformation occurs only under immune stress such as exposure to infectious pathogens. Heterozygous germline alterations in the PAX5 gene can lead to B-ALL upon accumulation of secondary mutations affecting the JAK/STAT signaling pathway. Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge. |